Parental origin of triploidy and D and G trisomy in spontaneous abortions.
نویسندگان
چکیده
A cytogenetic study of 15 triploid spontaneous abortuses, 12 trisomic abortuses, and their parents was carried out using the Q-banding technique. Polymorphic regions in abortus chromosomes were compared to corresponding regions of parental chromosomes to determine the origin of the extra chromosomes. Using marker chromosomes it was found that 7 triploids and only one trisomy were informative. Three triploids arose by failure to shed the second polar body during oogenesis. One triploid arose by dispermy. The other three triploids inherited an extra haploid set of chromosomes from the father, either by dispermy or by failure of the second meiotic division during spermatogenesis. The only informative trisomy, a trisomy 22, inherited the extra 22 from the mother. Chromosome polymorphisms are useful in determining the parental origin of extra chromosomes in certain cases.
منابع مشابه
Prenatal Diagnosis of Triploidy in Fetus with Unexpected Chromosomal Translocation of Maternal Origin
Triploidy is a lethal chromosomal abnormality. Foetuses with triploid condition have a tendency to die in early conception and very few survive to term. In this study, we report the prenatal diagnosis of fetal triploidy with unexpected chromosomal translocation. A 27 years old women was referred to our clinical cytogenetic department due to history of previous conceptus with intrauterine growth...
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Recently, there have been several molecular studies of trisomic fetuses and liveborns which have examined the parent and meiotic stage of origin of nondisjunction. However, little is known about the possible phenotypic effects of the origin of trisomy. For trisomic spontaneous abortions, no distinct phenotype has been described, although some have been reported to have features, such as trophob...
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First trimester spontaneous abortions occur in 15 to 20% of all clinically recognized pregnancies. Chromosomal -anomalies are responsible for more than 50% of spontaneous abortions. The majority (90%) of these chromosomal anomalies are numerical, particularly autosomal trisomies (involving chromosomes 13,16, 18, 21, 22), polyploidy and monosomy X. At birth chromosomal anomalies are still an imp...
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Several studies have been reported on the cytogenetic analysis of spontaneous abortions (Aspillage et al., 1966; Boue, Boue, and Lazar, 1967; Carr, 1967; Clendenin and Benirschke, 1963; Hall and Kallen, 1964; Inhorn, Therman, and Patau, 1964; Rashad and Kerr, 1965; Singh, Rubinoff, and Carr, 1966; Szulman, 1965; Thiede and Salm, 1964; Thiede and Metcalfe, 1966; Waxman, Arakaki, and Smith, 1967)...
متن کاملCytogenetic study of spontaneous abortion.
Sir It has been estimated that 25-40% or more pregnancies end in spontaneous abortions and that at least 80% happened in the first trimester!. There are many causes of spontaneous abortion, but it is now known that about 60% of abortuses expelled spontaneously in the first trimester are chromosomally abnormaF. The types of chromosomal abnormality usually found in abortuses are autosomal trisomy...
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ورودعنوان ژورنال:
- Journal of medical genetics
دوره 16 4 شماره
صفحات -
تاریخ انتشار 1979